John Kramer is back. The most disturbing installment of the Saw franchise yet explores the untold chapter of Jigsaw's most personal game. Set between the events of Saw I and II, a sick and desperate John travels to Mexico for a risky and experimental medical procedure in hopes of a miracle cure for his cancer only to discover the entire operation is a scam to defraud the most vulnerable. Armed with a newfound purpose, the infamous serial killer returns...

Bodies are turning up around the city, each having met a uniquely gruesome demise. As the investigation proceeds, evidence points to one suspect, John Kramer, the man known as Jigsaw, who has been dead for ten years.